What is Stem Cell: 2009

Monday, April 13, 2009

[StemCells] Make your own induced pluripotent stem cells

ArunA Biomedical Announces Co-development of Fully Validated Induced Pluripotent Stem Cell Kit

Comtex ATHENS, Ga., March 31, 2009 /PRNewswire via COMTEX/ ----ArunA Biomedical, Inc., a leader in human embryonic stem cell derived products, announced today that it has co-developed a validated kit to produce induced pluripotent stem cells with Open Biosystems now part of Thermo Fisher.

(Logo: http://www.newscom.com/cgi-bin/prnh/20080819/CLTU003LOGO)

In the spirit of collaboration ArunA Biomedical and Open Biosystems will launch the complete and fully validated induced pluripotent stem cell (iPS) kits containing all the tools and reagents necessary to generate patient and disease specific cell lines for use in research applications in early April. The innovative viPS(TM: 77.9649, -1.2687, -1.6%) product offerings will include two kit formats and additional supplemental kits designed exclusively by the companies.

ArunA co-founder and CSO, Steven Stice said, "These kits are consistent with the scientific vision of our company. They exemplify ArunA's commitment to making stem cell research easier thereby enabling investigators the opportunity to make faster advances in the stem cell field. Induced pluripotent cells generated from these kits can help find cures for many genetic disorders ranging from certain types of Alzheimer's to Huntington's disease. "

The products will be marketed by Open Biosystems, now part of Thermo Fisher. For more information please visit the product website at: www.thermo.com/openbiosystems

About ArunA Biomedical

Located in Athens, Georgia, ArunA Biomedical, Inc. is a privately held biotechnology corporation dedicated to the discovery, manufacturing and commercialization of emerging new technologies in human stem cell research for use in drug discovery and basic research. ArunA is the first company to commercialize products derived from human embryonic stem cells and sees its proprietary technology as a catalyst leading to the discovery of novel therapeutic compounds, tests for neurotoxicity and breakthroughs in understanding human development and diseases. For more information, visit: www.arunabiomedical.com

This press release contains forward-looking statements regarding the company's potential impact on scientific research and collaborations with third parties. Certain conditions could alter the outcome or progress of these statements including but not limited to unexpected manufacturing issues, product performance and quality control/assurance issues. Forward- looking statements are based on the opinions, beliefs and expectations of the company or individuals quoted in the press release and the company does not assume any obligation to update these forward-looking statements if circumstances change.

SOURCE ArunA Biomedical, Inc.

http://www.arunabiomedical.com
Copyright (C: 3.38, 0.31, 10.1%) 2009 PR Newswire. All rights reserved

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http://www.foxbusiness.com/story/aruna-biomedical-announces-development-fully-validated-induced-pluripotent-stem/

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StemCells subscribers may also be interested in these sites:

Children's Neurobiological Solutions
http://www.CNSfoundation.org/

Cord Blood Registry
http://www.CordBlood.com/at.cgi?a=150123

The CNS Healing Group
http://groups.yahoo.com/group/CNS_Healing
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Wednesday, April 8, 2009

[StemCells] A to Z in Stem cell

Hi friends,
Where can i get A to Z information in stem cells?

Raja Rajenderan
Junior Research Scientist
Pondicherry Biotech Pvt Ltd

[Non-text portions of this message have been removed]

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[StemCells] RE: Stem Cells on Oprah

Yeah for Dr. Oz! I usually don't agree with anything he says - (afterall,
he promotes irradiated food as safe, and he made a complete idiot of himself
trying to explain Oprah's thyroid problem) - but he's right - there has
been so much advancement on ADULT stem cells, that embryonic stem cell
research should be discontinued.

Carol

<http://groups.yahoo.com/group/StemCells/message/7028;_ylc=X3oDMTJxOTA2czFzB
F9TAzk3MzU5NzE1BGdycElkAzIxNzEzODcEZ3Jwc3BJZAMxNzA1MDgzMTA1BG1zZ0lkAzcwMjgEc
2VjA2Rtc2cEc2xrA3Ztc2cEc3RpbWUDMTIzOTE4MjQ3NQ--> Stem Cells on Oprah (video)

Posted by: "Mary (Ryan) Hamilton"
<mailto:GoFitz@holtbiz.com?Subject=%20Re%3AStem%20Cells%20on%20Oprah%20%28vi
deo%29> GoFitz@holtbiz.com <http://profiles.yahoo.com/go_fitz> go_fitz

"I think, Oprah, the stem cell debate is dead."
"The problem with embryonic stem cells is that embryonic stem cells come
from embryos, like all of us are made from embryos, and those cells can
become any cell in the body, but it's very hard to control them and so they
can become cancer."

[Non-text portions of this message have been removed]

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StemCells subscribers may also be interested in these sites:

Children's Neurobiological Solutions
http://www.CNSfoundation.org/

Cord Blood Registry
http://www.CordBlood.com/at.cgi?a=150123

The CNS Healing Group
http://groups.yahoo.com/group/CNS_Healing
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��

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Tuesday, April 7, 2009

[StemCells] SCs for deafness

New Stem Cell Therapy May Lead To Treatment For Deafness
ScienceDaily (Mar. 23, 2009) — Deafness affects more than 250 million people worldwide. It typically involves the loss of sensory receptors, called hair cells, for their "tufts" of hair-like protrusions, and their associated neurons. The transplantation of stem cells that are capable of producing functional cell types might be a promising treatment for hearing impairment, but no human candidate cell type has been available to develop this technology.

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See also:
Health & Medicine
Stem Cells
Hearing Loss
Lymphoma
Mind & Brain
Hearing Impairment
Perception
Neuroscience
Reference
Embryonic stem cell
Auditory system
Sensory neuron
Hair follicle
A new study led by Dr. Marcelo N. Rivolta of the University of Sheffield has successfully isolated human auditory stem cells from fetal cochleae (the auditory portion of the inner ear) and found they had the capacity to differentiate into sensory hair cells and neurons.

The researchers painstakingly dissected and cultured cochlear cells from 9- to 11-week-old human fetuses. The cells were expanded and maintained in vitro for up to one year, with continued division for the first 7 to 8 months and up to 30 population doublings, which is similar to other non-embryonic stem cell populations, such as bone marrow. Gene expression analysis showed that all cell lines expressed otic markers that lead to the development of the inner ear as well as markers expressed by pluripotent embryonic stem cells, from which all tissues and organs develop.

They were able to formulate conditions that allowed for the progressive differentiation into neurons and hair cells with the same functional electrophysiological characteristics as cells seen in vivo.

"The results are the first in vitro renewable stem cell system derived from the human auditory organ and have the potential for a variety of applications, such as studying the development of human cochlear neurons and hair cells, as models for drug screening and helping to develop cell-based therapies for deafness," say the authors.

Although the hair cell-like cells did not show the typical formation of a hair bundle, the authors suggest that future studies will aim to improve the differentiation system. They are currently working on using the knowledge gleaned from this study to optimize the differentiation of human embryonic stem cells into ear cell types.

"Although considerable information has been obtained about the embryology of the ear using animal models, the lack of a human system has impaired the validation of such information," the authors note.

"Access to human cells that can differentiate should allow the exploration of features unique to humans that may not be applicable to animal models," says Donald G. Phinney, co-editor of the journal. The protocol they developed to expand and isolate human fetal auditory stem cells may be able to be adapted for deriving clinical-grade cells with potential therapeutic applications.

Dr Ralph Holme, director of biomedical research for Royal National Institute for Deaf and Hard of Hearing People, said: "There are currently no treatments to restore permanent hearing loss so this has the potential to make a difference to millions of deaf people."

The study is published in the April issue of Stem Cells.

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Journal reference:

Wei Chen, Stuart L. Johnson, Walter Marcotti, Peter W. Andrews, Harry D. Moore, Marcelo N. Rivolta. Human Fetal Auditory Stem Cells (hFASCs) Can Be Expanded In Vitro And Differentiate Into Functional Auditory Neurons And Hair Cell-Like Cells (p N/A). Stem Cells, 2009; DOI: 10.1002/stem.62
Adapted from materials provided by Wiley - Blackwell.
Email or share this story:
Need to cite this story in your essay, paper, or report? Use one of the following formats:
APA

MLA Wiley - Blackwell (2009, March 23). New Stem Cell Therapy May Lead To Treatment For Deafness. ScienceDaily. Retrieved April 7, 2009, from http://www.sciencedaily.com /releases/2009/03/090323093129.htm

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[StemCells] Testes makes any cell body needs

GUMC Researchers Show Adult Human Testes Cells Can Become Embryonic Stem-like, Capable of Treating Disease

Washington, DC – Using what they say is a relatively simple method, scientists at Georgetown University Medical Center have extracted stem/progenitor cells from adult testes and have converted them back into pluripotent embryonic-like stem cells. Researchers say that the naïve cells are now potentially capable of morphing into any cell type that a body needs, from brain neurons to pancreatic tissue.

And because they produced these stem cells without the use of additional genes, the technology should be safe for human use, the researchers say in a paper published online in the journal Stem Cells and Development.

"Given these advances, and with further validation, it is possible that in the not–too-distant-future, men could be cured of disease with a biopsy of their own testes," says the study's senior investigator, Martin Dym, PhD, a professor in the Department of Biochemistry and Molecular & Cellular Biology.

The Georgetown researchers are among the first scientists to show that human testes stem cells can become embryonic-like stem cells, and they have done this work using testis tissue from organ donors, which they say has provided enough valuable tissue to allow them to make their discoveries. While they have published their preliminary results before, they are now disclosing a new and simpler method to isolate the testes stem/progenitor cells than has not been seen in other published procedures in humans and rodents.

Being able to use adult stem cells for this type of cell-based therapy offers a number of advantages over other strategies currently being explored, says Dym. The use of embryonic stem cells is controversial because it necessitates destruction of an embryo, and pushing fully mature cells, such as skin cells, back into a stem-like state requires use of cancer genes, and has therefore been viewed as potentially risky for human treatment, he says.

The idea with this approach is that men with an incurable disorder or disease could have a biopsy of their testes, which Dym says is a common procedure in patients suspected of having testicular cancer. Testes stem/progenitor cells – those cells that can go on to produce sperm – would be removed from the biopsy tissue, and grown in the laboratory with the addition of certain chemicals and growth factors. This causes the cells to revert back into a pluripotent state, which could then be driven into chosen cell types.

"We are taking adult spermatogonial stem/progenitor cells, which in the body are unipotent, capable of only making sperm, and coaxing them back to embryonic stem-like cells, which are pluripotent," Dym says.

Once these new cell types are produced – several weeks after initial collection – they can be frozen and used at any point in the future, the researchers say. He and the research team conducted the study using testes donated to GUMC from four organ donors, aged 16-52 years old.

"This is novel data which strengthens the argument for carrying out further research on pluripotent cells derived from human testes," Dym says.

The next step, he says, is to get differentiated cells to cure disease in animal models and the researchers are now working on a project that uses testes spermatogonial stem/progenitor cells that morphed into pancreatic cells to treat diabetes in mouse models of human diabetes.

The study was funded by a grant from the National Institutes of Health. The authors report no potential financial conflicts.

Co-authors include first author Nady Golestaneh, PhD, Ian Gallicano, PhD, and other Georgetown University Medical Center investigators in the Departments of Oncology and Obstetrics and Gynecology, the Lombardi Comprehensive Cancer Center, and in the Department of Biochemistry and Molecular & Cellular Biology. Colleagues from the Washington Regional Transplant Community also participated in the study.

About Georgetown University Medical Center
Georgetown University Medical Center is an internationally recognized academic medical center with a three-part mission of research, teaching and patient care (through our partnership with MedStar Health). Our mission is carried out with a strong emphasis on public service and a dedication to the Catholic, Jesuit principle of cura personalis -- or "care of the whole person." The Medical Center includes the School of Medicine and the School of Nursing and Health Studies, both nationally ranked, the world-renowned Lombardi Comprehensive Cancer Center and the Biomedical Graduate Research Organization (BGRO), home to 60 percent of the university's sponsored research funding.

FOR IMMEDIATE RELEASE: March 22, 2009

CONTACT:
Karen Mallet
215-514-9751
km463@georgetown.edu
###

http://explore.georgetown.edu/news/?ID=40657&PageTemplateID=295

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[StemCells] RE: Spina Bifida

Neural Stem Cells May Help Repair Spina Bifida in Utero [Outline] ... Pilot animal study shows promising results in the treatment of a th...(Vocus) September 9 2008 -- A pilot animal study led by researchers f... ...a href http://www.childrenshospital.org/az/Site1062/mainpageS1062P0...[RSS & Subscription]
http://www.bio-medicine.org/inc/biomed/medicine-news.asp
http://feeds.bio-medicine.org/latest-medical-news
Email Subscription: Get Latest Medical News delivered by emailDate:9/9/2008[Outline] [RSS & Subscription]

Pilot animal study shows promising results in the treatment of a this congenital defect before birth

(Vocus) September 9, 2008 -- A pilot animal study led by researchers from http://www.childrenshospital.org/az/Site1062/mainpageS1062P0.html [Children's Hospital Boston] provides preliminary evidence that delivering neural stem cells (NSC) into the spinal cord, along with surgical coverage of the defect while in utero, may help repair spina bifida before birth. The delivered cells engrafted selectively in the most damaged areas of the spinal cord, remained viable, and produced neurotrophic and neuroprotective factors locally, the first steps in initiating a reparative process. The findings appear in the September issue of the journal, Surgery.

http://www.childrenshospital.org/az/Site1062/mainpageS1062P0.html [Spina bifida] is a condition in which a portion of the spinal cord and its surrounding structures develop outside, instead of inside, the body. The defect develops at around the fourth week of gestation and can occur anywhere along the spine. Children with spina bifida suffer from partial paralysis, urinary and fecal incontinence, and musculoskeletal deformities. The condition has an overall mortality rate of 14 percent at 5 years.

Fetal surgery to repair this defect has been available for over a decade; however, the outcomes have shown limited improvement on spinal cord function. Only now is a large multicenter clinical trial comparing fetal repair to postnatal closure underway.

The Children's Hospital Boston researchers hypothesized that the surgery needs to be augmented by tissue regeneration techniques.

Dario Fauza, MD, of the Department of Surgery and '/>"/>

http://www.bio-medicine.org/medicine-news-1/Neural-Stem-Cells-May-Help-Repair-Spina-Bifida-in-Utero--26213-1/

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[StemCells] Stem Cells on Oprah (video)

Dr Mehmet Oz says to Michael J Fox, Oprah & ~7.2 million viewers:

"I think, Oprah, the stem cell debate is dead."
"The problem with embryonic stem cells is that embryonic stem cells come from embryos, like all of us are made from embryos, and those cells can become any cell in the body, but it's very hard to control them and so they can become cancer."

"I can take a little bit of your skin, take those cells, get them to go back in time so they are like they were when you were first made, and then they will start to make that dopamine & I think those cells, because they won't be as prone to cancer & because they're your genes will be the ones that are ultimately used to cure Parkinsons."

"I think we are single digit years away from making a big impact in the lives of Parkinson's disease but also diabetics, heart disease, people who have had a lot of problems."

you can see the video here:
http://www.oprah.com/media/20090319-tows-dr-oz-brain

http://repairstemcell.wordpress.com/2009/03/31/oprah-michael-j-fox-dr-mehmet-oz-the-stem-cell-debate-is-over/

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Monday, April 6, 2009

[StemCells] Stem Cells on Twitter

NT Media Corp. (http://www.ntmedia.tv) (OTCBB: NTMI), a developer and operator of online media websites, has added a real-time Twitter Tracker Feed to its recently launched targeted social network dedicated to the discussion of all aspects of Stem Cell research. The network, www.stemcellstalk.com, is equipped with text, photos, videos, blogs, forums and extensive social networking in the area of Stem Cell research. The site is intended to foster education and debate as well as networking opportunities for medical professionals, patients, and companies engaged in Stem Cell treatment and research. The site is an open social forum for anyone wishing to join and will also be selectively inviting Stem Cell professionals to address participants in online forums and discussions. The Stem Cell Twitter Tracker feature is ideal for those who simply want to monitor any discussion on Stem Cells.
"Twitter has become an enormously popular way for consumers to get information. Now, on Stemcellstalk.com, people can get up to the minute stem cell info from twitter," said NT Media CEO Ali Moussavi.

The live Twitter Tracker for Stem Cells can be viewed at: http://www.stemcellstalk.com/profile/NTMedia

http://pr-usa.net/index.php?option=com_content&task=view&id=194380&Itemid=95

http://www.stemcellstalk.com/

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Saturday, April 4, 2009

[StemCells] Spina Bifida

I'm a new member with Spina Bifida. I noticed that the only posts (3) on Spina Bifida mentioned bladder studies. Is there any other research being done with Spina Bifida, specifically for adults? I would think that if there are bladder studies there would be nerve generation studies.

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What is Stem Cell

Monday, April 13, 2009

[StemCells] Make your own induced pluripotent stem cells

Wednesday, April 8, 2009

[StemCells] A to Z in Stem cell

[StemCells] RE: Stem Cells on Oprah

Tuesday, April 7, 2009

[StemCells] SCs for deafness

[StemCells] Testes makes any cell body needs

[StemCells] RE: Spina Bifida

[StemCells] Stem Cells on Oprah (video)

Monday, April 6, 2009

[StemCells] Stem Cells on Twitter

Saturday, April 4, 2009

[StemCells] Spina Bifida

Do you know about Stem Cells?

stem cell links

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