What is Stem Cell: August 2008

Monday, August 25, 2008

[StemCells] Ozone/Stem Cell therapy

Hi. My son is a near drown and left in a semi conscience state with Infantile Spasms and
cortical blindness. I have been reading and reading on Stem cells for almost a year now. So
much bad comes out about each place (mexico, Dominican Republic, China).

1st. I want to know if anyone has a child like Santana's Condition that had stem cells done
with results and where did you go?

2nd. Has anyone done Ozone/stem cell therapy in Mexico with Dr. Estrada?

You can learn more about Santana at www.prayforsantana.org

Thanks for helping me!

Lindsey Black

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StemCells subscribers may also be interested in these sites:

Children's Neurobiological Solutions
http://www.CNSfoundation.org/

Cord Blood Registry
http://www.CordBlood.com/at.cgi?a=150123

The CNS Healing Group
http://groups.yahoo.com/group/CNS_Healing
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Sunday, August 24, 2008

[StemCells] simple pluripotent test to speed up research

Stem cells, show your face
By Patrick BarryWeb edition : Sunday, August 24th, 2008 Text Size A
new test distinguishes embryonic stem cells and those with equal
therapeutic potential from other, less capable stem cell types.Stem
cells' unassuming, bloblike appearance makes them hard to identify,
but new research offers a way to blow their cover.

The technique can distinguish embryonic stem cells — which are
pluripotent, meaning they can become any kind of cell in the body —
from "adult" stem cells that reside in people's organs and have a
much more limited repertoire.

Using the new test, Jeanne Loring of the Scripps Research Institute
in La Jolla, Calif., and her colleagues provide fresh evidence that
stem cells made by "reprogramming" a person's skin without ever
making or destroying an embryo are truly pluripotent, just like
embryonic stem cells.

The findings, reported online August 24 in Nature, suggest that these
reprogrammed, embryonic-like stem cells could be used for future stem
cell therapies in place of embryonic cells, which are more
controversial because they are extracted from embryos.

Scientists have debated whether reprogrammed cells truly have all the
abilities of cells taken from embryos.

"You can do a pretty simple test now and discover if it's
pluripotent, and you couldn't do that before," Loring says.

To distinguish adult stem cells from pluripotent cells, Loring's team
compared the gene activity of about 150 stem cell samples of various
types, including reprogrammed cells, embryonic stem cells and neural
stem cells. Out of this comparison popped 299 interacting genes that
form what the researchers call a pluripotency network, or PluriNet.
Measuring the activity of these genes could reliably distinguish the
different kinds of stem cells, the team reports.

"This is an exhaustive documentation of the essential gene expression
features of pluripotency and will be a helpful roadmap for scientists
working in this hot new area of biomedical research," says George
Daley of the Harvard Stem Cell Institute.

The way scientists have been testing the pluripotency of reprogrammed
mouse cells is to add reprogrammed cells to mouse embryos and see
whether the cells give rise to every type of body cell in the newborn
pups. Such tests are difficult to perform with human cells for
ethical reasons.

"People are always arguing about the differentiation potential and
therapeutic potential of each of the various stem cells," says Robb
MacLellan, a cardiologist at the UCLA David Geffen School of
Medicine. The new test is "going to help and speed up the development
of this whole field."

In 2006, Japanese researchers discovered a set of four genes that
when injected into skin cells reprogram those cells into an embryonic-
like state. Many of the 299 PluriNet genes encode proteins that are
activated by this process, Loring says.

The test also found distinctions among neural stem cells that
scientists had thought were the same, MacLellan notes. "There was a
lot of divergence in terms of what other people were calling neural
stem cells," he says. Identifying these previously unrecognized
subtypes could help scientists better understand the various roles
that the cells play in creating new nerve cells for the brain. "This
test will help to clarify some of that."

http://www.sciencenews.org/view/generic/id/35776/title/Stem_cells,_sho
w_your_face

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[StemCells] Medra's William Rader Questioned

August 24, 2008
Researchers skeptical of foreign treatment: American experts want
more scientific proof from Dr. William Rader about his methods.

(York Daily Record (PA) (KRT) Via Acquire Media NewsEdge) Aug. 24--
READ MORE: SAVING SHAWNA -- A search for hope

Since 1995, more than 1,000 patients have spent up to $30,000 for
stem cell treatments with Dr. William Rader, a Malibu, Calif.,
psychiatrist.

His Web site, www.medra.com, said that since 1995, he successfully
treated patients with epilepsy, multiple sclerosis, autism, cerebral
palsy, Parkinson's disease and AIDS at his Caribbean clinics.

U.S. researchers said his claims can't be believed until he follows
the rules of scientific medicine and publishes his research.

Fia Richmond is the founder of Children's Neurobiological Solutions
Foundation, a California-based nonprofit that funds U.S. stem cell
research. In 1999, she took her son Palmer, then 4, to Rader's
Bahamas clinic for treatment for a brain injury he's had since birth.
Instead of seeing improvement, Richmond said, he had an increased
number of seizures.

"(Rader) wasn't a neurologist," she said. "He wasn't able to assist
me."

It's been almost 10 years and Palmer still doesn't walk or talk.

Dr. Chi Van Dang, vice dean of research at Johns Hopkins University,
oversees the Hopkins Institute for Cell Engineering. He said it's
unfortunate, but there are doctors who exploit the desperation of
patients and their families. He said he doesn't know enough about
Rader to comment specifically on him.

Dang said he hopes these doctors have the answers to cure

man's most devastating diseases, but he hasn't seen any scientific
proof.

Richmond said Rader refuses to work with scientists to prove his work.

"If it's working," she said, "he should work to make it available for
everyone in this country and abroad."

Dang said, optimistically, the U.S. is still a few years away from
getting FDA approval to put stem cell treatments into clinical
trials. Using animal models, Dang said, the university researchers
are at the early stages of understanding the cells. Dealing with the
spine and brain is sensitive work, he said.

Rader didn't return phone calls for comment. But his Web site says
the treatment is harmless. In a video posted on the site, he
said, "In reality, I don't do anything. And the reason I am saying
that is all I do is put in the cells and then, nature, God, whatever
you want to say takes care of the rest. I don't tell them where to
go, I don't give them a diagnosis," he said.

His pitch brings parents from all over the world to relieve their
children's suffering, even though Richmond and others in the medical
community discourage it.

"The majority of parents will still go, because they are at the end
of their ropes," she said. "I feel like sometimes it doesn't matter
what I say."

nlefever@ydr.com; 771-2101

CONCEPT TO CONSUMER

The process to get a procedure or drug approved for consumer use is
long and involved.

Whoever develops the idea will typically seek to register and file
for patent protection. During the research process, scientists
subject their findings to peer review in medical literature. Animal
models are used for testing to get all the details correct. Then the
method must go through three phases of human clinical trials before
it will be approved by the FDA.

http://www.tmcnet.com/usubmit/2008/08/24/3616458.htm

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[StemCells] Tumor Detruction

Tumor Detruction

http://bioisolutions.blogspot.com/2008/06/tumor-destruction.html

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Thursday, August 21, 2008

[StemCells] Good Fat, Obesity, & SCs

'Good' Fat may Help to Treat Obesity: Study

Scientists have found two genetic triggers for producing
healthful "good" fat in mice, pointing the way to a new treatment for
obesity, according to a pair of studies published Thursday.

Harvard University researchers also made the startling discovery that
these so-called brown fat cells -- which burn calories rather than
store them -- originate from the same immature stem cells that
produce muscle.

While many people would prefer to have less of it, fat is essential
for health. It helps regulate our metabolism, and keeps our bodies
warm.

But there are two kinds of blubber.

White fat is composed of molecules that hoard calories, and has
contributed to a worldwide crescendo of obesity with consequences
ranging from diabetes to heart disease.

Brown fat, more prevalent in infants than adults, is different -- in
fact far more different that scientists realised.

To find out what chemicals in the body trigger its production, a team
of researchers led by Yu-Hua Tseng of the Joslin Diabetes Center at
Harvard Medical School experimented with genetically modified mice.

They discovered that a protein called BMP7 was critical to the
process: without it, brown fat cells failed to develop, causing the
mice to die. Added in artificially high doses, BMP7 had the opposite
effect.

But white fat, Tseng found, relied on different albeit related
chemicals to develop.

More importantly, he proved that white and brown fat do not originate
from the same precursor cells.

In the early phase of their development, the two types of fat cells
appear to be identical, so most scientists had assumed they derive
from a common source.

In the second study, Bruce Spiegelman of the Dana Farber Cancer
Institute, also at Harvard, found out -- to his "huge surprise" --
that brown fat comes actually from the same stem cells that produce
muscle tissue.

The key is a "master regulator" protein called PRDM16 that determines
which way these adult stem cells will develop.

"I think we now have very convincing evidence that PRDM16 can turn
cells into brown fat cells, with the possibility of combating
obesity," he said.

Though mature humans have relatively little brown fat, it is thought
to play a critical metabolising role.

Spiegelman said that finding a new potential source for this "good"
fat -- the adult stem cells, or myoblasts, that exist to replace
mature muscle cells -- open a path for boosting its calorie-burning
action to combat obesity.

Obesity is occurring at epidemic rates worldwide and is a major risk
factor for type 2 diabetes and metabolic syndrome, a bundle of health
problems including clogged arteries, heart attack and stroke.

Both studies were published in the British science and medical
journal Nature.

Source-AFP
SRM

http://www.medindia.net/news/Good-Fat-may-Help-to-Treat-Obesity-Study-
40859-1.htm

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Wednesday, August 20, 2008

[StemCells] E-Books

Hi friends,

I have some ebooks on biotech,molecular biology,biochemistry nanotech,

If u need any books pls send ur email id to
loyolite112000@yahoo.co.in,i will send you book.

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[StemCells] Own CB may help kids w/diabetes

New Approach To Juvenile Diabetes Gains Attention

The ongoing research-being conducted at the University of Florida-is
demonstrating that the severity of type 1 diabetes can be reduced by
giving children with the disease stem cells collected from their own
umbilical cords. Children in the study demonstrated lower blood sugar
levels and required less insulin (a hormone given to treat diabetes)
than the control group.

Type 1-or juvenile diabetes-is a disease that involves a failure of
the body's immune system to recognize its own cells as non-
threatening, leading how to clean upholstery destruction of insulin-
producing cells in the pancreas. Researchers believe that using stem
cells from one's own cord blood (referred to as autologous therapy)
might keep the immune system from attacking the pancreas and possibly
help stop progression or development of the disease.

Successful Treatments

Stem cells from umbilical cord blood have been used for more than 20
years to treat nearly 70 diseases including certain types of cancers
and blood disorders such as leukemia, lymphoma and sickle-cell
anemia. A decade ago, less than 1 percent of Americans were banking
cord blood. Today, that figure has grown to about 4 percent and is
rising, largely due to the impact that cord blood treatment may have
in regenerative medicine-the science of using the body's own cells to
repair damaged tissue upholstery cleaning mn organs. More than one in
three Americans, approximately 128 million people, could benefit from
regenerative therapies using stem cells from preferred sources like
cord blood. Regenerative medicine studies are already well under way
in a variety of therapeutic areas in addition to type 1 diabetes,
including heart disease, cerebral palsy, and spinal cord and brain
injuries.

Fighting Diabetes

The new links between cord blood stem cells and diabetes treatment
could be especially important, as the number of children diagnosed
with type 1 diabetes continues to increase.

Nearly 21 million Americans have some form of diabetes, resulting in
annual health care costs of $132 billion. Type 1 diabetes alone
affects one in every 300 children, a number expected to soon reach 3
to 5 percent annually. Diabetes affects the body's ability to process
sugar and can lead to a host of complications ranging from kidney
disease to memory loss drugs Since regenerative medicine focuses on
treatments designed to restore function in damaged tissue or organs,
this field has the potential to save millions of lives and billions
of dollars within our current health care system.

How To Bank Cord Blood

Expectant parents who want to preserve their newborn's cord blood for
future medical use should consider banking with an experienced family
cord blood bank, such as Cord Blood Registry (CBR).

http://www.corsavoo.com/diabetes/0,2577,452993,00.html

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[StemCells] Cancer Gene Expression

Cancer Gene Expression Trends Indentified in Developmental Stages:
Study

Scientists from Children's Hospital Boston and Harvard University
claim to have uncovered the trends in cancer gene expression in the
early developmental stages of different human tissues.

The team led by Isaac S Kohane performed a comprehensive comparison
of genes expressed in early developmental stages of various human
tissues and those expressed in different cancers affecting these
tissues.

"Our study reveals potentially clinically relevant differences in the
gene expression of different cancer types and represents a reference
framework for interpretation of smaller-scale functional studies," he
said.

One of the three described groups of cancers has an early
developmental phenotype and expresses genes that are characteristic
of stem cells.

A second, more heterogeneous group tends to be more similar to late
development and is characterized by an inflammatory signature.

The third is a small group of cancers that present as a transition
phenotype between these two extremes and displays both
characteristics.

"This segregation of tumors into three groups with distinct
expression patterns is surprising. Clearly, the developmental
trajectory provides a meaningful background for capturing large-scale
differences in gene expression across diverse conditions," said
Kohane.

The research is published in BioMed Central's open access journal
Genome Biology.

Source-ANI
THK/L
http://www.medindia.net/news/Cancer-Gene-Expression-Trends-
Indentified-in-Developmental-Stages-Study-40717-1.htm

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[StemCells] Bowel Cancer SC marker Lamin A

Bowel cancer indicator should lead to better treatment
Contact: Claire Whitelaw
media.relations@durham.ac.uk
44-191-334-6075
Public Library of Science

STEM cell scientists have developed a more accurate way of
identifying aggressive forms of bowel cancer, which should eventually
lead to better treatment and survival rates.

The UK-led team, headed by scientists from Durham University and the
North East England Stem Cell Institute, (NESCI*), studied tissue
samples from 700 colorectal cancer patients and tracked their
progress.

They found that patients who had a stem cell marker protein called
Lamin A present in their tissue were more likely to have an
aggressive form of the disease.

The team concluded that if the marker is detected in the early forms
of colorectal cancer, these patients should be given chemotherapy in
addition to the surgery normally offered to ensure a better survival
predicament.

The team now aims to develop a robust prognostic tool for use in the
health service.

The study, funded by the Association for International Cancer
Research and NHS Research and Development funds, is published in the
open-access scientific journal PLoS ONE.

The Durham University/NESCI scientists worked with colleagues from
The James Cook University Hospital, Middlesbrough, and the
Departments of Pathology and Epidemiology at the University of
Maastricht in the Netherlands.

Bowel cancer is the third most common cancer in the UK, where each
year more than 36,000 people are diagnosed with the disease.
Worldwide over a million new cases of bowel cancer were diagnosed in
2002.

Almost three-quarters of bowel cancer cases occur in people aged 65
and over. The development of disease is linked with diet, lifestyle
and environmental factors. (Source of statistics: Cancer Research UK
fact sheet).

In colorectal cancer, there are four key stages of the disease. The
stage of a patient's cancer is determined by a series of hospital
tests, the results of which inform the treatment they are given.

In the two earlier stages, before the cancer involves the lymph
nodes, patients normally have an operation to remove the cancer from
the bowel. They are rarely given chemotherapy in addition to the
surgery. This is because for many patients, who are often elderly and
frail, chemotherapy may cause more harm than benefit. It's therefore
critical to know when and in whom it should be used.

However, the new study suggests that around one third of these
patients will express the Lamin A stem cell marker, which indicates a
more serious form of the cancer. These patients, argue the
scientists, should be given chemotherapy to target these stem cells,
which should ultimately improve their recovery and survival rates.

Professor Chris Hutchison, of Durham University and NESCI,
said: "Currently the hospitals use a standard test to work out how
far the cancer has progressed and then they use this to determine the
treatment the patient should receive. However, we are potentially
able to more accurately predict who would benefit from chemotherapy."

Dr Stefan Przyborski, of Durham University and NESCI, said: "We now
aim to carry out more work in this area to develop a prognostic tool
which we hope will eventually be for widespread use by the health
services in the treatment of bowel cancer."

Professor Robert Wilson, a consultant surgeon and bowel cancer
specialist at The James Cook University Hospital, Middlesbrough,
said: "We have a very high number of patients with bowel cancer in
the north east of England in particular. We know the best treatment
for very early and very late disease but there are still a lot of
unknowns in-between these two extremes.

"Chemotherapy can be very useful but can have a number of side
effects, so we only want to use it where we think there's a good
chance it will help. This test will help us determine that."

###
* 'The North-east England Stem Cell Institute (NESCI) draws together
Durham and Newcastle Universities, the Newcastle-upon-Tyne Hospitals
NHS Foundation Trust and other partners in a unique interdisciplinary
collaboration to convert stem cell research and technologies into
cost-effective, ethically-robust 21st century health solutions to
ameliorate degenerative diseases, the effects of ageing and serious
injury. The Institute has received substantial funding and other
support from the Regional Development Agency, One NorthEast and is
partly based at the International Centre for Life in Newcastle.'
http://www.nesci.ac.uk/

MEDIA INFORMATION:

Interviews:

Professor Chris Hutchison: +44(0) 191 334 1270; Availability: 2pm-5pm
Tuesday August 19; 9-2pm Wednesday August 20. Or contact Durham
University Media Relations Office +44(0) 191 334 6075;
media.relations@durham.ac.uk
Prof Robert Wilson, consultant surgeon, The James Cook University
Hospital, Middlesbrough: Contact the hospital's Public Relations
Department: Lesley Connor: +44(0) 1642 854 343.
Images available from Durham University media relations office:

North News pictures of Prof Chris Hutchison and Dr Stefan Przyborski
in a laboratory setting
A head shot of Prof Robert Wilson
Scientific image from the paper: This shows bowel cancer tissue
stained for the presence of the stem cell marker lamin A. (The top
four panels show cancers that are negative for lamin A and these
patients showed high rates of survival. The bottom four panels show
cancers that were positive for lamin A and these patients showed poor
rates of survival).
Contact:

Durham University Media Relations Office:
Tel: +44(0) 191 334 6075
Email: media.relations@durham.ac.uk
Web: www.durham.ac.uk/news

Citation: Willis ND, Cox TR, Rahman-Casas SF, Smits K, Przyborski SA,
et al. (2008) Lamin A/C Is a Risk Biomarker in Colorectal Cancer.
PLoS ONE 3(8): e2988. doi:10.1371/journal.pone.0002988

PLEASE ADD THE LINK TO THE PUBLISHED ARTICLE IN ONLINE VERSIONS OF
YOUR REPORT (URL live from Aug 20):
http://dx.plos.org/10.1371/journal.pone.0002988

PRESS-ONLY PREVIEW: http://www.plos.org/press/pone-03-08-hutchison.pdf

Disclaimer

The following press release refers to an upcoming article in PLoS
ONE. The release has been provided by the article authors and/or
their institutions. Any opinions expressed in this are the personal
views of the contributors, and do not necessarily represent the views
or policies of PLoS. PLoS expressly disclaims any and all warranties
and liability in connection with the information found in the release
and article and your use of such information.

http://www.genengnews.com/news/bnitem.aspx?name=40687889

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[StemCells] Blood cells from hES claims by company on verge of shutting down

Stem cells could allow "blood farms," company says
Tue Aug 19, 2008 3:37pm EDT

Stem cells could allow "blood farms," company says

WASHINGTON (Reuters) - Embryonic stem cells can be used to grow vats
of red blood cells, which could lead to the creation of "farms" that
could provide limitless sources of blood, U.S. researchers reported
on Tuesday.

The team at Massachusetts-based Advanced Cell Technology hopes the
finding might help save the struggling company, which is desperately
seeking investors to keep it afloat.

"I think it's really a big break for us," said Dr. Robert Lanza,
scientific director of the company, one of a few commercial ventures
trying to make a business out of the emerging stem cell field.

Stem cells are the body's master cells, replenishing various cells
and tissues as they die. Stem cells taken from days-old embryos are
especially powerful, with the ability to produce any cell type.

Doctors hope to some day use them to provide tailor-made transplants
for patients, and to study disease. One problem is that the immune
system may reject tissues grown from someone else's stem cells.

Red blood cells may be an exception to this, because they do not have
a nucleus, Lanza and colleagues at the University of Illinois at
Chicago and the Mayo Clinic reported. "You don't have to worry about
the DNA going haywire," he said.

What Lanza envisions is growing batches of cells from human embryos
possessing all the different blood types: A, B, O and AB, as well as
negative and positive Rh versions of each.

O negative, considered "universal" because it can be transfused
safely into anyone possessing any of the other types, would be the
most desirable, Lanza said.

The researchers first coaxed embryonic stem cells into
differentiating into blood precursor cells, and then found a way to
get them to go down the road of becoming erythrocytes -- the red
blood cells that carry oxygen through the body.

The cells carried oxygen correctly and appeared capable of delivering
it to tissue, they reported.

"We can currently generate up to a 100 billion red blood cells from a
single six-well plate of stem cells," Lanza said.

The U.S. federal government strictly limits its funding of embryonic
stem cell research because of controversies over the use of human
embryos.

Lanza said his team was now trying to make blood cells using induced
pluripotent stem cells -- a new source of stem cells made using
ordinary skin cells and several genes that re-program them back to an
embryonic-like state.

But funding for such research is hard to come by, Lanza said.

"Right now, it's tough," said Lanza, whose company is down to 12
employees. "For a while we had the phones off. It's tough going but
the people who are here, we believe in this and we are riding it out."

(Editing by Julie Steenhuysen)
http://www.reuters.com/article/rbssHealthcareNews/idUSN194880042008081
9

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What is Stem Cell

Monday, August 25, 2008

[StemCells] Ozone/Stem Cell therapy

Sunday, August 24, 2008

[StemCells] simple pluripotent test to speed up research

[StemCells] Medra's William Rader Questioned

[StemCells] Tumor Detruction

Thursday, August 21, 2008

[StemCells] Good Fat, Obesity, & SCs

Wednesday, August 20, 2008

[StemCells] E-Books

[StemCells] Own CB may help kids w/diabetes

[StemCells] Cancer Gene Expression

[StemCells] Bowel Cancer SC marker Lamin A

[StemCells] Blood cells from hES claims by company on verge of shutting down

Do you know about Stem Cells?

stem cell links

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