Bone Marrow Stem Cells Used To Regenerate Skin
ScienceDaily (Jan. 19, 2009) — A new study suggests that adult bone
marrow stem cells can be used in the construction of artificial skin.
The findings mark an advancement in wound healing and may be used to
pioneer a method of organ reconstruction. The study is published in
Artificial Organs.*
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See also:
Health & Medicine
Skin Care
Stem Cells
Skin Cancer
Psoriasis
Leukemia
Bone and Spine
Reference
Skin grafting
Healing
Human physiology
Wound
To investigate the practicability of repairing burn wounds with
tissue-engineered skin combined with bone marrow stem cells, the
study established a burn wound model in the skin of pigs, which is
known to be anatomically and physiologically similar to human skin.
Engineering technology and biomedical theory methods were used to
make artificial skin with natural materials and bone marrow derived
stem cells. Once the artificial skin was attached to the patient and
the dermal layer had begun to regenerate, stem cells were
differentiated into skin cells. The cells are self-renewing and raise
the quality of healing in wound healing therapy. When grafted to the
burn wounds, the engineered skin containing stem cells showed better
healing, less wound contraction and better development of blood
vessels.
Skin, the human body's largest organ, protects the body from disease
and physical damage, and helps to regulate body temperature. When the
skin has been seriously damaged through disease or burns, the body
often cannot act fast enough to repair them. Burn victims may die
from infection and the loss of plasma. Skin grafts were originally
developed as a way to prevent such consequences.
"We hope that this so-called `engineered structural tissue' will
someday replace plastic and metal prostheses currently used to
replace damaged joints and bones by suitable materials and stem
cells," says Yan Jin of the Fourth Military Medical University, lead
author of the study.
*Artificial Organs is the official journal of the International
Federation for Artificial Organs (IFAO), the The International
Faculty for Artificial Organs (INFA) and the International Society
for Rotary Blood Pumps (ISRBP).
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Journal reference:
Liu et al. Tissue-Engineered Skin Containing Mesenchymal Stem Cells
Improves Burn Wounds. Artificial Organs, 2008; 32 (12): 925 DOI:
10.1111/j.1525-
Adapted from materials provided by Wiley-Blackwell.
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StemCells subscribers may also be interested in these sites:
Children's Neurobiological Solutions
http://www.CNSfoundation.org/
Cord Blood Registry
http://www.CordBlood.com/at.cgi?a=150123
The CNS Healing Group
http://groups.yahoo.com/group/CNS_Healing
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