The brain's reserve cells can be activated after stroke
[PRESS RELEASE, 23 February 2009] Scientists at Karolinska Institutet
have found a way of activating the neuronal reserves in the brains of
mice by switching off the signal that inhibits the formation of new
nerve cells. The study is presented in the online edition of the
scientific journal Nature Neuroscience.
Jonas Frisén
Photo: Stefan Zimmerman"So far, this is just basic research of no
immediate practical significance, but the results are very exciting
nonetheless,
and Molecular Biology, who led the study.
New nerve cells are formed from stem cells in specific areas of the
human brain. This process increases after a stroke, something that
might explain the recovery that is often observed in patients,
particularly in the first year following the onset of illness. In the
present study, the scientists have demonstrated how a type of cell
that does not give rise to new cells in the healthy brain is
activated after a stroke in laboratory animals.
In addition to the stem cells that are normally active, there is
therefore also a kind of reserve stock of cells the can be activated
when demand increases. The team have identified the molecular
mechanisms that control the activation of these cells, and shown that
it is possible to increase the formation of new nerve cells in
healthy mice by switching off the so-called Notch signalling pathway,
which inhibits the creation of new nerve cells.
journal Nature Neuroscience.
Publication
Marie Carlén, Konstantinos Meletis, Christian Göritz, Vladimer
Darsalia, Emma Evergren, Kenji Tanigaki, Mario Amendola, Fanie
Barnabé-Heider, Maggie S Y Yeung, Luigi Naldini, Tasuku Honjo, Zaal
Kokaia, Oleg Shupliakov, Robert M Cassidy, Olle Lindvall & Jonas
Frisén
Forebrain ependymal cells are Notch-dependent and generate
neuroblasts and astrocytes after stroke
Nature Neuroscience AOP, 22 February 2009, doi 10.1038/nn.2268
Download press image
For further information, please contact:
Professor
Jonas Frisén
Phone: +46 (0)8-524 875 62 E-mail: Jonas.Frisen@
Department of Cell and Molecular Biology
http://ki.se/
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StemCells subscribers may also be interested in these sites:
Children's Neurobiological Solutions
http://www.CNSfoundation.org/
Cord Blood Registry
http://www.CordBlood.com/at.cgi?a=150123
The CNS Healing Group
http://groups.yahoo.com/group/CNS_Healing
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