University of Miami trials give diabetics reason for hope
Clinical trials overseen by the University of Miami's Diabetes Research Center
show dramatic results in treatment of type 2 diabetes.
BY FRED TASKER
tasker@MiamiHerald.
Human trials under way at the University of Miami and other hospitals in Europe,
Asia and Latin America using immature adult stem cells are showing promise for
people with type 2 diabetes.
In a UM clinical trial recently published in the online journal Cell
Transplantation, 25 patients achieved better insulin production, lower
blood-sugar levels and reduced need for insulin injections.
In the trial, still in its pilot stage, doctors extracted immature adult stem
cells from the patients' own bone marrow, purified and concentrated them, and
injected them into arteries near the pancreas. They then put the patients into
hyperbaric oxygen chambers like those used for divers with decompression
sickness -- also called the ''bends'' -- and subjected them to 10 hours of pure
oxygen at 2.4 times the atmospheric pressure at ground level.
Researchers believe the high-pressure oxygen pulled extra stem cells from the
patients' bone marrow, adding to the stem cells injected near the pancreas. They
say the immature stem cells developed into pancreatic cells, regenerating the
pancreas' ability to produce natural insulin.
''This could be very important,'' said Dr. Camillo Ricordi, director of the Cell
Transplant Center and the Diabetes Research Institute at UM. ``It could be an
improved treatment for diabetes, substantially ameliorating type 2 and
preventing the complications of the disease.''
Nearly 8 percent of the U.S. population -- 24 million people -- has diabetes,
which can cause problems for the eyes, kidneys, nerves and heart, according to
the Centers for Disease Control and Prevention.
Ricordi cautioned that the optimistic findings come from small pilot studies
involving only dozens of patients, and three to four more years of research are
needed before practical treatments might start.
''We always have to avoid hype and be careful not to put too much hope in pilot
trials,'' Ricordi said. ``But the first results are really promising.''
Two more successful trials over three or four years would be needed before the
FDA might approve the treatment. The studies, coordinated by UM's Diabetes
Research Institute, will also take place at the Karolinska Institutet in
Stockholm, Stem Cell Argentina in Buenos Aires and other institutions.
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StemCells subscribers may also be interested in these sites:
Children's Neurobiological Solutions
http://www.CNSfoundation.org/
Cord Blood Registry
http://www.CordBlood.com/at.cgi?a=150123
The CNS Healing Group
http://groups.yahoo.com/group/CNS_Healing
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