Mechanism regulating growth, differentiation of adult muscle stem
cells identified
Posted December 8th, 2007 by Mohit JoshiWashington, Dec 8:
A recent study has revealed the mechanism which regulates the growth
and differentiation of muscle stem cells that aid in repairing
injured muscles.
The study was carried by a group of scientists led by Pier Lorenzo
Puri, MD, Ph. D. at the Burnham Institute for Medical Research in La
Jolla, CA.
Muscle regeneration is a natural response to injury and disease.
During this process, environmental signals lead to adult muscle stem
cells (satellite cells) to shift from dormancy to actively building
new muscle tissue.
However, the signaling pathways controlling muscle regeneration are
fairly well known, but the mechanism through which signals lead to
altered chromatin structure remains a mystery.
The researchers analyzed the governing mechanism of certain cellular
signaling cues, which cause epigenetic modifications at the time of
release within the regenerative microenvironment, hence controlling
the expression of genes regulating growth and differentiation of
muscle stem cells that repair injured muscle.
The team of scientists demonstrated the mechanism though which two
signaling pathways, PI3K/AKT and p38, work together to amass
components of the protein complexes responsible for muscle-specific
transcription, and how each pathway is responsible for a distinct
step in the transcription process.
Moreover, the team was able to separate these two steps
pharmacologically, showing that selective interference with either
cascade cause incomplete assembly of protein complexes, and in the
process prevent muscle-specific gene expression.
The findings indicate possible pharmacological avenues for selective
control of gene expression in adult muscle stem cells that may have
therapeutic potential in regenerative medicine.
The study was published in Molecular Cell. (ANI)
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Children's Neurobiological Solutions
http://www.CNSfoundation.org/
Cord Blood Registry
http://www.CordBlood.com/at.cgi?a=150123
The CNS Healing Group
http://groups.yahoo.com/group/CNS_Healing
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