Safer way to make human stem-like cells revealed
December 5, 2007
Shinya Yamanaka of Kyoto University in Japan has refined his method
for making human skin cells behave like embryonic stem cells so that
it does not use a cancer-causing agent.
Late last month, Yamanaka reported making pluripotent cells — cells
that can turn into any of the roughly 220 cell types in the body — by
using retroviruses to carry four genes into human skin cells (K.
Takahashi et al. Cell 131, 861–872; 2007). The four genes
reprogrammed the cells into a state similar to that of cells in the
early embryo. But one of the genes used to make the cell lines is c-
myc, which can cause cancer.
Yamanaka has now shown that he can make these 'induced pluripotent
stem cells' in both humans and mice by using just three factors — not
including c-myc (M. Nakagawa et al. Nature Biotechnol.
doi:10.1038/
http://www.nature.
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StemCells subscribers may also be interested in these sites:
Children's Neurobiological Solutions
http://www.CNSfoundation.org/
Cord Blood Registry
http://www.CordBlood.com/at.cgi?a=150123
The CNS Healing Group
http://groups.yahoo.com/group/CNS_Healing
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