New Technique Produces Intermediate-
Plentifully Than Previous Methodologies
Main Category: Stem Cell Research
Article Date: 27 Feb 2008 - 2:00 PST
PrimeGen Biotech has announced that company researchers have
successfully used purified proteins and DNAs in non-viral methods to
reprogram adult human cells into stem cells.
Participating in this week's Stem Cell Summit in New York, the
company reported that this new class of stem cells -- derived from
adult human tissues such as skin -- has properties of embryonic stem
cells (ESC), as well as stem cells referred to as "induced
pluripotent stem cells" or iPS cells.
Relying on a high efficiency particle delivery system to transport
proteins and DNA molecules directly into cells from human skin,
retina and kidney, researchers found that after one week, stem cell
colonies arose that exhibited the markers of ESC and iPS cells. They
also found that PrimeGen's reprogramming technology is orders of
magnitude more efficient and three to four times faster than previous
viral methods - requiring just a week or two, rather than a month or
more, to display the pluripotent markers.
Unlike iPS cells produced by other investigators in the US and Japan,
PrimeGen researchers are the first to use methods that do not involve
potentially tumor-causing viruses or genetic manipulations. And
unlike embryonic stem cells, these methods use adult skin and other
tissues from the patient, not embryos. As such, the company continues
in its mandate to produce high quality cells that will be suitable
for future patient therapies.
"We believe these new methods for making iPS cells could solve many
inherent problems and offer great promises for translation into
clinical trials," said John S. Sundsmo, President, PrimeGen
Biotech. "Because these methods are so rapid and efficient, we
believe they may provide a springboard into therapies that use a
patient's own cells to prepare stem cells, thus, eliminating graft
rejection and risks of graft versus host disease. We see these
results as a critical step towards bringing safe, ethical,
individualized stem cell treatments into the clinic."
PrimeGen has submitted its results, as scientific abstracts, to the
6th International Society of Stem Cell Research Annual Meeting, to be
held in Philadelphia this June. Cells from PrimeGen Biotech are also
currently being studied in several independent academic labs.
About PrimeGen Biotech LLC
PrimeGen Biotech is dedicated to the research and therapeutic
applications of adult stem cells, leading to individualized patient
therapies. Entering its fifth year of operations at the pre-clinical
stage of product development, the company specializes in two core
technologies: germ line stem cells and therapeutic reprogramming.
Pioneering work on induced pluripotent stem cells (iPS cells),
positions PrimeGen as a leader in moving this breakthrough from
research to therapy. Future applications of both PrimeGen core
technologies will enlist a patient's own adult tissue cells to
generate stem cells for regenerative and restorative medical
treatments. Based in Irvine, California, PrimeGen Biotech is a
privately held, Delaware limited liability company.
PrimeGen Biotech LLC
http://www.medicaln
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StemCells subscribers may also be interested in these sites:
Children's Neurobiological Solutions
http://www.CNSfoundation.org/
Cord Blood Registry
http://www.CordBlood.com/at.cgi?a=150123
The CNS Healing Group
http://groups.yahoo.com/group/CNS_Healing
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