Post brain injury: New nerve cells originate from neural stem cells
In the study group of Prof. Dr. Magdalena Götz in the Institute of
Stem Cell Research of the Helmholtz Zentrum München and Ludwig
Maximilians-
the understanding of processes to be able to substitute for injured
brain cells after accidents. Stem cells that originate from
supporting cells can evolve again into new nerve cells.
[Translate to Englisch:] Prof. Magdalena Goetz
Most cells in the human brain are not nerve cells, but supporting
cells (glial cells). They serve as a framework for nerve cells and
play an important role in the wound reaction that occurs with
injuries to the brain. However, what these `reactive glial cells' in
the brains of mice and men originate from, and which cells they
evolve into was hitherto unknown.
Now, the study group of Prof. Dr. Magdalena Götz is able to show that
after injury, these reactive glial cells in the brains of mice
restart their cell division. They then become stem cells from which
nerve cells can form yet again under favourable cell culture
conditions.
With this came the ground-breaking proof that, in an injured region
of the brain, adult neural stem cells exist that could later serve as
a source of new nerve cells.
In her study group, the stem cell expert, Magdalena Götz, examines
the molecular bases of cerebral development, in particular in the
cerebral cortex. Götz proved in earlier investigations that glial
brain cells can act as stem cells, and nerve cells emerge from glial
cells. She also pointed out which factors play a role in the cross-
over from glial to neural cells. "Now, thanks to these results, the
distant goal of being able to use the processes therapeutically is
getting a little closer" stresses Götz.
Original publication:
Annalisa Buffo, Inmaculada Rite, Pratibha Tripathi, Alexandra Lepier,
Dilek Colak, Ana-Paula Horn, Tetsuji Mori, and Magdalena
Götz: "Origin and progeny of reactive gliosis: a source of multi-
potent cells in the injured brain"; PNAS published 25 February, 2008,
10.1073/pnas.
Press office contact
Helmholtz Zentrum München - German Research Center for Environmental
Health (GmbH), Heinz-Jörg Haury, Head of Public Affairs, Ingolstädter
Landstraße 1 85764 Neuherberg, Tel.: 089-3187-2460. Email
presse@helmholtz-
Neuherberg, 2008-03-11
http://www.helmholt
2008/press-releases
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StemCells subscribers may also be interested in these sites:
Children's Neurobiological Solutions
http://www.CNSfoundation.org/
Cord Blood Registry
http://www.CordBlood.com/at.cgi?a=150123
The CNS Healing Group
http://groups.yahoo.com/group/CNS_Healing
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