Friday, January 18, 2008

[StemCells] Cloning Human Males - the paper

Read the paper here - still many question ...Can the clone females
(the centrosome is paternally derived in humans)? How will they
identify the epigentic problems that ALL clones have (per Ian
Wilmut)? How many women will be exploited and die? Will there ever
be a case where stem cells from a clone ever cure anything?

Read the paper here:
http://stemcells.alphamedpress.org/cgi/reprint/2007-0252v1.pdf

An article:
Scientists produce embryo clones of 2 men, using skin cells in step
toward stem cell goal
The Associated PressPublished: January 17, 2008

NEW YORK: Scientists in California say they have produced embryos
that are clones of two men, a potential step toward developing
scientifically valuable stem cells.

The new report documents embryos made with ordinary skin cells. But
it is not the first time human cloned embryos have been made. In
2005, for example, scientists in Britain reported using embryonic
stem cells to produce a cloned embryo. It matured enough to produce
stem cells, but none were extracted.

Stem cells were not produced by the new embryos either, and because
of that, experts reacted coolly to the research.

"I found it difficult to determine what was substantially new," said
Doug Melton of the Harvard Stem Cell Institute. He said the "next big
advance will be to create a human embryonic stem cell line" from
cloned embryos. "This has yet to be achieved."

Dr. George Daley of the Harvard institute and Children's Hospital
Boston called the new report interesting but agreed that "the real
splash" will be when somebody creates stem cell lines from cloned
human embryos.

"It's only a matter of time before some group succeeds," Daley said.

Korean scientist Hwang Woo-suk claimed a few years ago that he'd
created such cell lines, but that turned out to be a fraud.

Dr. Samuel Wood, a co-author of the new paper and chief executive of
Stemagen Corp. of La Jolla, California, said he and his colleagues
are now attempting to produce stem cell lines from the embryos.

The work was published online Thursday by the journal Stem Cells.

Scientists say stem cells from cloned embryos could provide a
valuable tool for studying diseases, screening drugs and, perhaps
someday, creating transplant material to treat conditions like
diabetes and Parkinson's disease.

But critics raise objections. The process "involves creating human
lives in the laboratory solely to destroy them for alleged benefit to
others," said Richard Doerflinger, spokesman for the U.S. Conference
of Catholic Bishops.

Citing the earlier work in Britain, he also said that as a scientific
advancement, the new work was "very limited."

Other objections to cloning include concerns about health risks and
exploitation if large numbers of women are asked to provide eggs.

Those objections are one reason that an alternative route to stem
cells made headlines last November. Scientists reported a relatively
simple way to turn skin cells directly into stem cells. This direct
reprogramming carries a theoretical risk of cancer for the recipients
of tissue from these cells, however, and many scientists have urged
that work continue on the cloning technique as well.

The cloning approach involves inserting DNA from a person into an
egg, and then growing the egg into an embryo about five days old
before extracting the stem cells. At that stage, the embryo is a
sphere of about 150 cells.

In the new work, researchers took skin cells from Wood and another
volunteer and produced three embryos with DNA matching the men's.
Further DNA testing on one of these embryos strengthened the case
that it was a clone, researchers said.

http://www.iht.com/articles/ap/2008/01/17/america/NA-MED-US-Cloned-
Embryos.php

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StemCells subscribers may also be interested in these sites:

Children's Neurobiological Solutions
http://www.CNSfoundation.org/

Cord Blood Registry
http://www.CordBlood.com/at.cgi?a=150123

The CNS Healing Group
http://groups.yahoo.com/group/CNS_Healing
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