Novel Neural Stem Cell Type Identified
Main Category: Stem Cell Research
Also Included In: Neurology / Neuroscience
Article Date: 15 Jan 2008 - 3:00 PST
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Researchers from the Sloan-Kettering Institute, led by Dr. Lorenz
Studer, have discovered a novel type of neural stem cell, which has a
broader differentiation potential than previously identified neural
stem cells.
In culture, neural stem cells (NSCs) can readily differentiate into
neuronal and glial subtypes, but their ability to differentiate into
region-specific neuronal cell types is limited. Dr. Studer and
colleagues isolated and cloned a population of neural rosette cells
(R-NSCs), which have an expanded neuronal subtype differentiation
potential.
Dr. Studer and colleagues demonstrate that R-NSCs can differentiate
along both the CNS and PNS lineages, and are capable of in vivo
engraftment. Furthermore, the researchers identified biomarkers
unique to the R-NSC type, as well as signaling pathways required for
the maintenance of the R-NSC type.
"Our data suggest that R-NSCs may represent the first neural cell
type capable of recreating the full cellular diversity of the
mammalian nervous system. As such, R-NSCs should have a major impact
for applications in regenerative medicine and have the potential to
become the "embryonic stem cell equivalent" of the nervous system,"
explains Dr. Studer.
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Article adapted by Medical News Today from original press release.
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StemCells subscribers may also be interested in these sites:
Children's Neurobiological Solutions
http://www.CNSfoundation.org/
Cord Blood Registry
http://www.CordBlood.com/at.cgi?a=150123
The CNS Healing Group
http://groups.yahoo.com/group/CNS_Healing
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