Pancytopenia MDS may reflect stromal changes and longer time to
engraftment post transplant
Submitted by Dross on Thu, 2008-01-17 04:06. More on: aml | mds
Pancytopenia MDS may reflect stromal changes and longer time to
engraftment post transplant
It has recently been shown that patients with myelodysplastic
syndrome (MDS) may find that their time to stem cell engraftment post
transplant is delayed beyond that seen by Acute Myeloid Leukemiaterm
transplant patients (a more serious disease.) The thought behind
these results is that the bone marrow's stroma (matrix cells) was not
providing sufficient signal to the blood progenitor cells before the
transplant took place, whereas the AML patients may have had
progenitor cells with more serious mutations in their dna which would
not have responded properly even if the stroma's signals were being
provided. Therefore in many AML patients, transplanted stem cells are
able to engraft quickly because the matrix environment is healthy and
able to support the division and growth of new progenitors.
Please inform your physician of these findings.
Time to engraftment following allogeneic stem cell transplantation is
significantly longer in patients with myelodysplastic syndrome than
with acute myeloid leukemia
M Bitan1, R Or1, M Y Shapira1, I B Resnick1, B Gesundheit1, A
Ackerstein1, S Samuel1, S Elad2 and S Slavin1
1Department of Bone Marrow Transplantation and Cancer Immunotherapy,
Hadassah University Hospital, Jerusalem, Israel
2Oral Medicine Department The Hebrew University-Hadassah School of
Dental Medicine, Jerusalem, Israel
Correspondence: Dr S Slavin, Department of Bone Marrow
Transplantation and Cancer Immunotherapy, Hadassah University
Hospital, PO Box 12000, Jerusalem 91120, Israel. E-mail:
slavin@tapuz.
Received 5 February 2007; Revised 5 July 2007; Accepted 10 July 2007;
Published online 12 November 2007.
Bone Marrow Transplantation (2008) 41, 69–78;
doi:10.1038/
http://www.nature.
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StemCells subscribers may also be interested in these sites:
Children's Neurobiological Solutions
http://www.CNSfoundation.org/
Cord Blood Registry
http://www.CordBlood.com/at.cgi?a=150123
The CNS Healing Group
http://groups.yahoo.com/group/CNS_Healing
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