Adult Stem Cells Beneficial In Heart Failure Recovery
Main Category: Cardiovascular / Cardiology
Also Included In: Stem Cell Research
Article Date: 28 Jan 2008 - 1:00 PST
A study in the Clinical and Experimental Pharmacology and Physiology
published by Wiley-Blackwell shows that administration of adult bone
marrow stem cells (BMC) and mesenchymal stems cells (MSC) can aid in
the recovery of myocardial infarction (MI) - commonly known as heart
attack - and consequently increase survival rates.
The study - "Systemic Delivery of Adult Stem cells Improves Cardiac
Function in Spontaneously Hypertensive Rats" - is designed to
evaluate the impact of systemic delivery of BMC and MSC on
spontaneously hypertensive rats induced with MI.
Lead author, Dr. Nardi says "Our research is the first to show this
type of stem cell activity in a physiological model of MI, as we used
spontaneously hypertensive rats which closely represent the disease
in humans."
The treatment with stem cells resulted in statistically different
mortality rates- 0% for rats treated with BSC, 17% for rats treated
with MSC and 45% for non-treated rats. Rats that were treated also
showed significant recovery of heart function and capacity.
"Results suggest that injected BMC can bring about therapeutic
effects, especially in tissue regeneration. It speeds up the adaptive
remodeling of the heart and consequently increases survival rates",
says Dr. Nardi.
Although many studies have shown the potential beneficial effects of
stem cell therapies in treatment for heart failure, delivery methods
are still under investigation.
Author of the editorial commentary in this issue, John Haynes
says "In this issue, Nardi and co-workers have demonstrated
significant improvement in cardiac function and reduction in
mortality of the rats following the administration of BSC bringing us
closer to unraveling the mystery of the stem cell."
About Clinical and Experimental Pharmacology and Physiology
Clinical and Experimental Pharmacology and Physiology provides a
medium for the rapid publication of original research papers, short
communications, rapid communications and theoretical articles
(hypotheses) on the results of clinical and experimental work in
pharmacology and physiology. Invited review articles are published
occasionally.
Wiley-Blackwell
Wiley-Blackwell was formed in February 2007 as a result of the
acquisition of Blackwell Publishing Ltd. by John Wiley & Sons, Inc.,
and its merger with Wiley's Scientific, Technical, and Medical
business. Together, the companies have created a global publishing
business with deep strength in every major academic and professional
field. Wiley-Blackwell publishes approximately 1,400 scholarly peer-
reviewed journals and an extensive collection of books with global
appeal. For more information on Wiley-Blackwell, please visit
http://www.blackwel
About Wiley
Founded in 1807, John Wiley & Sons, Inc. has been a valued source of
information and understanding for 200 years, helping people around
the world meet their needs and fulfill their aspirations. Since 1901,
Wiley and its acquired companies have published the works of more
than 350 Nobel laureates in all categories: Literature, Economics,
Physiology/Medicine
Our core businesses include scientific, technical, medical and
scholarly journals, encyclopedias, books, and online products and
services; professional/
training materials, and online applications and websites; and
educational materials for undergraduate and graduate students and
lifelong learners. Wiley's global headquarters are located in
Hoboken, New Jersey, with operations in the U.S., Europe, Asia,
Canada, and Australia. The Company's Web site can be accessed at
http://www.wiley.
Exchange under the symbols JWa and JWb.
John Wiley & Sons, Inc.
http://www.medicaln
«¤»¥«¤»§«¤»¥«¤»§«¤»¥«¤»«¤»¥«¤»§«¤»¥«¤»§«¤»¥«
¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯
StemCells subscribers may also be interested in these sites:
Children's Neurobiological Solutions
http://www.CNSfoundation.org/
Cord Blood Registry
http://www.CordBlood.com/at.cgi?a=150123
The CNS Healing Group
http://groups.yahoo.com/group/CNS_Healing
____________________________________________
«¤»¥«¤»§«¤»¥«¤»§«¤»¥«¤»«¤»¥«¤»§«¤»¥«¤»§«¤»¥«
¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯
Earn your degree in as few as 2 years - Advance your career with an AS, BS, MS degree - College-Finder.net.
Change settings via the Web (Yahoo! ID required)
Change settings via email: Switch delivery to Daily Digest | Switch format to Traditional
Visit Your Group | Yahoo! Groups Terms of Use | Unsubscribe
__,_._,___
No comments:
Post a Comment