What is Stem Cell: [StemCells] SCs may contribute to vascular disease

Friday, May 16, 2008

[StemCells] SCs may contribute to vascular disease

Stem Cells Might Contribute To Vascular Disease - Stem Cells Might
Cause More Damage After Vascular Surgery

Article Date: 15 May 2008 - 4:00 PDT

Physician-scientists believe that stem cells might play a harmful
role in the body's reaction to trauma following common vascular
surgery, like angioplasty. A team of scientists - led by Dr. K. Craig
Kent, Greenberg-Starr Professor and professor of surgery at Weill
Cornell Medical College and chief of the Division of Vascular Surgery
at NewYork-Presbyterian - are currently studying how stem cells
implant themselves in the wall of arteries and grow out of control.
Commonly, a blockage re-forms following angioplasty (termed re-
stenosis) near the area where the procedure was performed.

The researchers observed that a chemical in the body called
transforming growth factor beta (TGFb), which stimulates tissue
growth, is released in high levels inside the artery following the
trauma of angioplasty. Dr. Kent believes this happens because TGFb
beckons stem cells to the irritated area to heal the wound.

This leads to the growth of dense, artery-blocking tissue. If the
scientists can learn how to shut off this response, Dr. Kent believes
great progress might be made in the treatment of recurring heart
disease.

NewYork-Presbyterian Hospital/Weill Cornell Medical Center

NewYork-Presbyterian Hospital/Weill Cornell Medical Center, located
in New York City, is one of the leading academic medical centers in
the world, comprising the teaching hospital NewYork-Presbyterian and
Weill Cornell Medical College, the medical school of Cornell
University. NewYork-Presbyterian/Weill Cornell provides state-of-the-
art inpatient, ambulatory and preventive care in all areas of
medicine, and is committed to excellence in patient care, education,
research and community service. Weill Cornell physician-scientists
have been responsible for many medical advances - from the
development of the Pap test for cervical cancer to the synthesis of
penicillin, the first successful embryo-biopsy pregnancy and birth in
the U.S., the first clinical trial for gene therapy for Parkinson's
disease, the first indication of bone marrow's critical role in tumor
growth, and, most recently, the world's first successful use of deep
brain stimulation to treat a minimally-conscious brain-injured
patient. NewYork-Presbyterian, which is ranked sixth on the U.S.News
& World Report list of top hospitals, also comprises NewYork-
Presbyterian Hospital/Columbia University Medical Center, Morgan
Stanley Children's Hospital of NewYork-Presbyterian, NewYork-
Presbyterian Hospital/Westchester Division and NewYork-Presbyterian
Hospital/The Allen Pavilion. Weill Cornell Medical College is the
first U.S. medical college to offer a medical degree oversees and
maintains a strong global presence in Austria, Brazil, Haiti,
Tanzania, Turkey and Qatar.

NewYork-Presbyterian Hospital
Weill Cornell Medical Center
http://www.medicalnewstoday.com/articles/107478.php

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StemCells subscribers may also be interested in these sites:

Children's Neurobiological Solutions
http://www.CNSfoundation.org/

Cord Blood Registry
http://www.CordBlood.com/at.cgi?a=150123

The CNS Healing Group
http://groups.yahoo.com/group/CNS_Healing
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