Study could lead to stem-cell breakthrough
Updated Thu. Apr. 3 2008 11:56 AM ET
CTV.ca News Staff
A new study suggests that women who have babies from donor-egg
pregnancies have fetal cells in their systems years after giving
birth.
In a small study of 11 healthy women, researchers found that fetal
cells from a donor-egg pregnancy survived for at least nine years
after five of the mothers gave birth. All five of the women had
delivered boys.
The finding is significant because fetal cells from a donor egg
pregnancy are genetically foreign to the mother, as half are from the
father and half from the egg donor.
Fetal cells live for decades in a mother following a normal
pregnancy, but that is due to the fact that half of the genetic
material comes from her.
Because the mother did not reject the foreign tissues, these findings
could be a first step toward developing treatments from stem cells
donated by embryos.
The study was conducted by researchers from Brigham and Women's
Hospital in Boston. The findings were published in the online edition
of Fertility and Sterility.
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Abstract
Objective
To determine whether allogenic fetal cells resulting from donor egg
pregnancies persist in maternal circulation.
Design
Nested polymerase chain reaction (PCR) amplification of the DYS14
sequence, a region of the Y chromosome, from DNA purified from
peripheral blood cells.
Setting
Academic medical center.
Patient(s)
Healthy 18-60-year-old women who have had donor egg pregnancies
resulting in a male offspring (n = 11) or, as a control, female
offspring (n = 8), at least 1 year previously and without any other
source for male cells in their peripheral blood or a healthy male.
Intervention(
None.
Main Outcome Measure(s)
Detection of DYS14 sequence by nested PCR.
Result(s)
DYS14 was detected in 5/11 (45%) of women who had donor egg
pregnancies resulting in a male offspring, but in 0/8 (0) of women
who had donor egg pregnancies resulting in a female offspring. The
longest interval between delivery of a male offspring and detection
of the DYS14 gene was 9 years.
Conclusion(s)
Unmatched, allogenic fetal cells from donor egg pregnancies are able
to persist in the circulation of healthy women for at least 9 years
after delivery. This implies a novel mechanism by which immunologic
detection is avoided by these cells and may impact on how they may be
used for regenerative and transplant medicine.
Link to Full Study(registration required)
http://www.ctv.
dy_080403/20080403?
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StemCells subscribers may also be interested in these sites:
Children's Neurobiological Solutions
http://www.CNSfoundation.org/
Cord Blood Registry
http://www.CordBlood.com/at.cgi?a=150123
The CNS Healing Group
http://groups.yahoo.com/group/CNS_Healing
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