Scientists Uncover Stem Cell Gene's Role in Mammary Cell Development
GEN News Highlights
April 14, 2008
Researchers at Georgetown University Medical Center discovered that
the gene Musashi1 (Msi1) associated with human breast stem cells
stimulates mammary cell development by activating two pathways.
Recent studies have implicated Msi1 as a human stem cell marker,
since it has been found in human breast, colon, brain, skin, and
other cells, according to the scientists. They found that Msi1 drives
mammary cells along different lineages; i.e., it can decide what type
of cell develops in the breast. The researchers also observed that
Msi1 is expressed in particularly aggressive tumors. Furthermore,
they showed that Msi1 regulates Wnt and Notch pathways in mammary
cells. Both these pathways help control stem-cell growth and are
known to be critically important to the development of many cancers.
Studying how Msi1 drives the Wnt and Notch pathways, the
investigators also noted that when Msi1 was overexpressed, there was
an increased secretion of a growth factor known as proliferin and
reduced secretion of the Wnt pathway inhibitor Dickkopf-3.
Additionally, Msi1 programmed the expression of a number of genes
that have an effect on the cell cycle, they report.
The findings were reported at the annual meeting of the American
Association for Cancer Research.
http://www.genengne
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StemCells subscribers may also be interested in these sites:
Children's Neurobiological Solutions
http://www.CNSfoundation.org/
Cord Blood Registry
http://www.CordBlood.com/at.cgi?a=150123
The CNS Healing Group
http://groups.yahoo.com/group/CNS_Healing
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