Tissue-specific blood stem cell line established from embryonic stem
cells
Science Centric | 28 April 2008 17:52 GMT
A research team at the Umea Centre for Molecular Medicine (UCMM) in
Sweden, led by Professor Leif Carlsson, has managed to specifically
establish and isolate the tissue-specific stem cell that produces
blood cells (blood stem cell) by using genetically modified embryonic
stem cells.
A deeper understanding of the regulation of blood stem cells is
important if we are to be able to further develop treatments for
diseases that require bone marrow transplants, such as leukaemia,
immune deficiencies, and anaemia disorders. Blood stem cells are
unique in that they can both continually generate all types of blood
cells and also produce new stem cells, so-called self-regeneration.
These two properties are the basic reason why we have a functioning
blood system throughout our lives and why bone marrow transplants are
a functional treatment method.
An understanding of how tissue-specific stem cells are produced and
regulated is absolutely essential for us to be able to develop forms
of treatment in so-called regenerative medicine, that is, where
damaged tissue needs to be replaced by new tissue. On source of
transplantable cells for this purpose is embryonic stem cells, since
they have a unique capacity to generate different types of tissues.
But one of the major problems with embryonic stem cells is to be able
to establish and isolate tissue-specific stem cells, such as blood
stem cells, from these cells in a reproducible manner.
Even though the process of self-regeneration is well known, the
molecular mechanisms that underlie it are largely unknown. The fact
that it is now possible to establish and isolate blood stem cells
from embryonic stem cells in a reproducible way will yield key
insights into the molecular mechanisms that regulate the function of
blood stem cells and will thereby lead to enhanced methods of
treatment for patients who need bone marrow transplants, such as
leukaemia patients.
Source: Swedish Research Council
http://www.sciencec
«¤»¥«¤»§«¤»¥«¤»§«¤»¥«¤»«¤»¥«¤»§«¤»¥«¤»§«¤»¥«
¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯
StemCells subscribers may also be interested in these sites:
Children's Neurobiological Solutions
http://www.CNSfoundation.org/
Cord Blood Registry
http://www.CordBlood.com/at.cgi?a=150123
The CNS Healing Group
http://groups.yahoo.com/group/CNS_Healing
____________________________________________
«¤»¥«¤»§«¤»¥«¤»§«¤»¥«¤»«¤»¥«¤»§«¤»¥«¤»§«¤»¥«
¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯
Change settings via the Web (Yahoo! ID required)
Change settings via email: Switch delivery to Daily Digest | Switch format to Traditional
Visit Your Group | Yahoo! Groups Terms of Use | Unsubscribe
__,_._,___
No comments:
Post a Comment